
Play Alien Syndrome Online
Alien Syndrome is a scrolling shooter.
Your job is to run around and rescue all the captives and make it to the escape hatch before the time bomb explodes. Then face the mother alien at the end of the level.
Available Versions
Alien Syndrome (USA, Europe) (1986)(Master System)
Alien Syndrome (Japan) (1986)(Master System)
Alien Syndrome (set 1, Japan, old, System 16A, FD1089A 317-0033) (1986)(Arcade)
Alien Syndrome (set 2, System 16A, FD1089A 317-0033) (1986)(Arcade)
Alien Syndrome (set 3, System 16B, FD1089A 317-0033) (1986)(Arcade)
Alien Syndrome (set 4, System 16B, unprotected) (1986)(Arcade)
Alien Syndrome (set 5, System 16A, FD1089B 317-0037) (1986)(Arcade)
Alien Syndrome (set 6, Japan, new, System 16B, FD1089A 317-0033) (1986)(Arcade)
Alien Syndrome (set 7, System 16B, MC-8123B 317-00xx) (1986)(Arcade)
Alien Syndrome Series
How to Play Alien Syndrome in Your Browser
1. Click Play
Simply click the "Play Now" button at the top of this page to start the game immediately.
2. Use Controls
Use your keyboard to control the game. Check the keyboard configuration section below for details.
3. Save Progress
Use the save feature to preserve your progress at any point in the game.
Pro Tip
For the best experience playing Alien Syndrome, use a desktop or laptop computer with a keyboard. Full-screen mode provides the most immersive gameplay.
Emulator Keyboard Configuration

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Last updated: 2025-04-19T14:35:23.978Z
This page is part of our effort to preserve classic video game history. Alien Syndrome © 1986 SEGA Enterprises Ltd.. This online emulation is provided for historical preservation and educational purposes only.
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